Our team
The MaDOx group has a core of individuals and borrows on the clinical expertise of other groups both within and outside of the Department of Primary Health Care at Oxford University.
We are particularly active in the areas of new diagnostic technologies horizon scanning, vascular disease, oral anticoagulation therapy, hypertension and diabetes.

Annette joined the Centre for Monitoring and Diagnosis (MaDOx) in the Oxford University Department of Primary Health Care in January 2009. She is the director of the Diagnostic Horizon Scanning Programme and her research aims to identify innovations in diagnostic technologies likely to have a significant impact in primary care, and disseminating this information to the Health Technology Assessment (HTA) Programme, the National Institute for Health and Clinical Excellence (NICE) and Commissioning bodies. In particular, her research is focussed on the diagnosis of infection, cardiovascular disease and cancer. She is also attached to the Centre for Evidence Based Medicine at Oxford University.
She obtained her PhD from the University of Stellenbosch in South Africa and her background is in Microbiology and Immunology. From 2003-2008 she worked as a postdoctoral researcher under Prof. Siamon Gordon at the Sir William Dunn School of Pathology in Oxford, studying the role of macrophages in innate immunity against microbial infection.


David joins the Deparment from Kings College Hospital where he successfully set up the hospital's new cardiopulmonary exercise testing service. David completed his doctorate assessing the autonomic function of heart failure and transplant patients from Brunel University in June 2009. Work involved the assessment of heart rate variability in patients being assessed for heart transplant and treated with ventricular assist devices at Harefield hospital. David also has a background as an exercise physiologist and is accredited with the British Association of Sport and Exercise Sciences (BASES). David was also the director of the Human Performance Laboratory at Kingston University from 2004 to 2009 and worked as a lecturer at Kingston during that time, when he also completed a Masters in Sports Science from Brunel University.

Ann is a GP from Belgium who contributing on many projects in MaDOx. Ann is a regular attendee to meetings and commutes to Oxford from Belgium every 4th week.

Carl Heneghan is a Clinical Lecturer in the Department of Primary Health Care, University of Oxford, Deputy Director of the Centre of Evidence-Based Medicine and a General Practitioner. He has had an association with the Centre for Evidence-Based Medicine since 1995. He currently is a Walport Clinical Lecturer having previously held a NCCRD Research Development Fellowship.
His Research projects involve cardiovascular disease, self-monitoring in chronic diseases, and determining the evidence base for treatment of infections. He is a co-applicant on the £3.5million pound NIHR funded centre for Monitoring and Diagnosis in Oxford (MADOX). He works with the Oxford Vascular Study (OXVASC), a joint collaboration between the Departments of Clinical Neurology and Primary Health Care, and with the University of Birmingham on projects related to oral anticoagulation, the prevention of venous thrombosis and hypertension management, including self monitoring and tele-monitoring.
As a clinical epidemiologists Dr Heneghan has experience in systematic reviews, observational and quantitative methodologies: he collaborates with Dr Matthew Thompson on a number of diagnostic projects and infection related projects, including antiviral treatments of influenza and treatments ofr upper respiratory infections, and is a Co-Director of the Oxford Diagnostic Horizon Scanning Centre, an effective early warning system that identifies innovations in the field of health technology likely to have a significant impact. Dr Heneghan also collaborates with Dr Rafael Perera on monitoring methods and articles related to teaching of research methods and Evidence-Base Practice.
He has considerable experience in teaching for undergraduates, postgraduates and teachers of EBM practice and is an Msc Course module co-ordinator, tutor and supervisor at the Department of Continuing Education, University of Oxford. He has co-authored the EBM toolkit (BMJ-Blackwell’s), the Statistics Toolkit (BMJ-Blackwell’s) and is lead editor of a commissioned series of BMJ-Blackwell’s toolkits. He is involved in work that promotes the understanding and teaching of critical appraisal.
Carl is currently a reviewer for the Department of Health, NIHR Health Technology Assessment (HTA) Programme review board and is a member of the Pharmaceutical Panel, is Resource review editor with the Journal of Evidence-Based Medicine and is on the Advisory Boards of the Healthcare Compliance Packaging Council (HCPC), National Knowledge Decision Support Board and the BMJ Evidence Centre.

Matthew is a General Practitioner who has trained and worked in both the United Kingdom and the USA. He is currently a Senior Clinical Scientist in the Department, and also works as a family doctor in Oxford.
He is Co-Director of the Oxford Centre for Monitoring and Diagnosis (MaDOx) which is a research programme of primary and secondary research into more effective ways of monitoring chronic conditions and making diagnoses in primary care settings. His research is primarily in the field of diagnosis, this includes research on diagnosing serious illness in children in primary care, better ways of using diagnostic technologies, and prediction rules in primary care. He also coordinates the ERNIE group, which is a collaborative research study between the Universities of Oxford, Leicester, Leuven (Belgium), Maastricht, and Rotterdam (NL). The ERNIE research is examining earlier ways of recognising serious illness in children in primary care and emergency department settings. His other research interests include systematic reviews of therapies and diagnostics, and is involved in the Cochrane Acute Respiratory Infections group. Matthew also participates in the clinical teaching of medical students, and evidence based medicine as part of the MSc in EBM as well as the postgraduate courses of the Centre for Evidence-based Medicine.

Jane Wolstenholme joined the Health Economics Research Centre in December 1998, having previously worked at the University of Nottingham . Her main research interests lie in the areas of economic evaluation and health technology assessment from applied and methodological perspectives. During 2005 she was engaged on projects in modelling cost-effectiveness of prostate cancer screening and cervical cancer screening; economic evaluation alongside a RCT for the treatment of subarachnoid aneurysm; assessing the usefulness of cost-effectiveness data in priority setting. She is currently co-supervising two PhD students and one research officer and involved with teaching the MSc in global health and the HERC Advanced Methods course. She is an Associate of the Oxford Institute for Ageing and a member of the Health Economics Futures Group.

Jason's background was initially in biological sciences and then later in statistics. He completed his Masters in Biometry from Reading University in 2007. His interests are Bayesian statistics and R.

Jenny joined the Department of Primary Health Care in September 2009 as a Systematic Reviewer and Epidemiologist. She works within the Centre for Monitoring and Diagnosis (MaDOx) where she is involved in the diabetes group, conducting systematic reviews both on renal monitoring and the optimal prescribing of glucose lowering therapy.
Jenny previously worked in the medical diagnostics industry where she looked into potential new disease areas and diagnostic methods in the fields of cardiology, infectious disease and oncology.

Kathy joined the department in February 2010. Her background was initially mathematics and operational research applied to clinical and health policy problems, with a particular focus on heart disease. For her doctoral thesis, she developed a computer-based model for planning and evaluating shifts in health services and considered the case of cardiac catheterisation services in the NHS. Her previous post was in medical careers research in the Department of Public Health at Oxford University.

Nia is an information specialist and outreach librarian working with clinical staff, students and researchers in cancer services, public health and primary care. She has experience of teaching information skills within EBM programmes and regularly contributes to preparing systematic reviews.

Paul is Director of the Centre for Evidence-Based Medicine (www.cebm.net), and is chairman of the EBM Thread course for the Oxford medical students, and Editor of the Evidence-Based Medicine Journal. His research and teaching interests included improving the accessibility and use of research evidence in medical decision making, single-patient trials, monitoring, and methods to assess the generalisability of clinical trials and systematic reviews. He is a member of the management committee of several large clinical trials (LIPID, FIELD, and ADVANCE). He has published over 100 scientific papers and four books: "Decision Making in Health Care: Integrating Evidence and Values", "Systematic Reviews in Health Care", "Evidence-Based Medicine: How to Practice & Teach EBM", and the Evidence-Based Medicine Workbook

Professor Farmer undertook his DM thesis in the University Department of Diabetes and Endocrinology at Oxford, having completed vocational training at Thame Health Centre where he worked as a principal in the practice from 1985 to 2000. Between 2001 and 2006 he was a Senior Research Fellow in the Department of Primary Health Care holding an NHS R&D Senior Clinical Scientist Award. He also works as a salaried general practitioner at South Oxford Health Centre and is a Senior Research Fellow in the Diabetes Trials Unit.
His work has focussed on research to improve the self-management of diabetes in general practice including the best use of blood glucose monitoring, supporting adherence to medication, and evaluating the use of telehealth to improve long-term outcomes. He was a Harkness Fellow of the Commonwealth Fund of New York in 1991, one of the first general practitioners to hold this award. He currently has additional roles as Director of the Oxford Primary Care Trials Unit, Clinical Lead for the NIHR Thames Valley Diabetes Local Research Network and Deputy Chair of the NIHR Health Technology Assessment Programme Commissioning Board.

Chris Price is a Visiting Professor in Clinical Biochemistry at the University of Oxford and has recently joined the MaDOx team. He is also currently the Clinical Director of the Cumbria and Lancashire Pathology Commissioning Network. He brings strong links to the hospital laboratory community and the diagnostics industry, as well as contributing a commissioning perspective on diagnostics. His main interests are in point-of-care testing and evidence-based laboratory medicine.

Rafael is a University Lecturer in Medical Statistics, Co-director and the Head of Statistics for MaDOX. His general interests include: monitoring in primary care, meta-analysis methods, methodology for studying infectious diseases in children, and assessing complex interventions.

Richard joined the Department of Primary Health Care in 2008 as part of the Oxford Centre for Monitoring and Diagnosis (MADOx), where he is a senior statistician under the direction of Rafael Perera, and collaborates on a variety of MADOx projects including blood pressure monitoring and cholesterol monitoring in general practice. His research interests include clinical prediction rules, arising from his work on the UK Prospective Diabetes Study Risk Engine for calculating cardiovascular risk in people with diabetes.


Susan has worked as Senior Medical Statistician at CSM, University of Oxford since 2002 and joined MaDOx in 2010 and divides her time over the departments Her work has included a review of the methods used for systematic reviews of diagnostic tests and the design and analysis of primary studies in diagnosis including CT colonography and CT urology. She has also worked on methods for the development and assessment of performance of prognostic studies in cancer and is involved in the design of a prospective prognostic study to develop a prognostic index for the prediction of metastasis in colorectal cancer. Susan has a BA in Biochemistry and a DPhil in molecular immunology from Oxford, and a Diploma in Statistics. Other previous areas of research included immunology, virology, and infectious disease epidemiology.

Susannah Fleming trained as an engineer, and completed her DPhil in Biomedical Engineering in 2010. She has extensive experience in biomedical signal analysis and data fusion, and has been working in collaboration with primary care clinicians since 2006.
In 2010, Susannah was awarded a Research Fellowship from the National School of Primary Care Research, based in Oxford. She is currently involved in research into novel technologies for diagnosis and monitoring.

